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Accumulating evidence established a positive association of anti-heat shock protein 60 (HSP60) autoantibodies and the presence of atherosclerosis in humans. However, whether these autoantibodies play a causal role in the development of atherosclerosis is unknown.

Anti–Heat Shock Protein 60 Autoantibodies Induce Atherosclerosis in Apolipoprotein E–Deficient Mice via Endothelial Damage