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The β 2 -adrenoceptor (β 2 -AR), a prototypical GPCR (G protein-coupled receptor), couples to both G s and G i proteins. Stimulation of the β 2 -AR is beneficial to humans and animals with heart failure presumably because it activates the downstream G i -PI3K-Akt cell survival pathway. Cardiac β 2 -AR signaling can be regulated by crosstalk or heterodimerization with other GPCRs, but the physiological and pathophysiological significance of this type of regulation has not been sufficiently demonstrated.

Heterodimerization With 5-HT 2B R Is Indispensable for β 2 AR-Mediated Cardioprotection

Heterodimerization With 5-HT _2B R Is Indispensable for β ₂ AR-Mediated Cardioprotection