Open AccessNovel Paracrine Functions of Smooth Muscle Cells in Supporting Endothelial Regeneration Following Arterial Injury
Author(s) -
Jun Ren,
Ting Zhou,
Vijaya S. Pilli,
Noel Phan,
Qiwei Wang,
Kartik Gupta,
Zhenjie Liu,
Nader Sheibani,
Bo Liu
Publication year - 2019
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.118.314567
Subject(s) - paracrine signalling , gene knockdown , microbiology and biotechnology , conditional gene knockout , vascular smooth muscle , chemokine , knockout mouse , cxc chemokine receptors , biology , cxcl1 , immunology , medicine , inflammation , receptor , apoptosis , chemokine receptor , endocrinology , phenotype , smooth muscle , biochemistry , gene
Regeneration of denuded or injured endothelium is an important component of vascular injury response. Cell-cell communication between endothelial cells and smooth muscle cells (SMCs) plays a critical role not only in vascular homeostasis but also in disease. We have previously demonstrated that PKCδ (protein kinase C-delta) regulates multiple components of vascular injury response including apoptosis of SMCs and production of chemokines, thus is an attractive candidate for a role in SMC-endothelial cells communication.
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