Open AccessMacrophage Liver Kinase B1 Inhibits Foam Cell Formation and Atherosclerosis
Author(s) -
Zhaoyu Liu,
Huaiping Zhu,
Xiaoyan Dai,
Cheng Wang,
Ye Ding,
Ping Song,
MingHui Zou
Publication year - 2017
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.117.311546
Subject(s) - foam cell , scavenger receptor , macrophage , lipoprotein , ldl receptor , immune system , low density lipoprotein , biology , apolipoprotein e , chemistry , microbiology and biotechnology , endocrinology , cholesterol , medicine , immunology , in vitro , biochemistry , disease
LKB1 (liver kinase B1) is a serine/threonine kinase and tumor suppressor, which regulates the homeostasis of hematopoietic cells and immune responses. Macrophages transform into foam cells upon taking-in lipids. No role for LKB1 in foam cell formation has previously been reported.
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