Open AccessCell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic Cells
Author(s) -
Mingtao Zhao,
NingYi Shao,
Shijun Hu,
Nan Ma,
Rajini Srinivasan,
Fereshteh Jahanbani,
Jaecheol Lee,
Sophia Zhang,
M Snyder,
Joseph C. Wu
Publication year - 2017
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.117.311367
Subject(s) - biology , enhancer , induced pluripotent stem cell , chromatin , reprogramming , cell type , epigenetics , h3k4me3 , epigenomics , regulation of gene expression , microbiology and biotechnology , dna methylation , embryonic stem cell , cellular differentiation , chromatin immunoprecipitation , somatic cell , stem cell , promoter , genetics , gene expression , gene , cell
Regulatory DNA elements in the human genome play important roles in determining the transcriptional abundance and spatiotemporal gene expression during embryonic heart development and somatic cell reprogramming. It is not well known how chromatin marks in regulatory DNA elements are modulated to establish cell type-specific gene expression in the human heart.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom