Open AccessExploring the Causal Pathway From Telomere Length to Coronary Heart Disease
Author(s) -
Yiqiang Zhan,
Ida Karlsson,
Robert Karlsson,
Annika Tillander,
Chandra A. Reynolds,
Nancy L. Pedersen,
Sara Hägg
Publication year - 2017
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.116.310517
Subject(s) - mendelian randomization , odds ratio , telomere , waist , confidence interval , medicine , body mass index , diabetes mellitus , metabolic syndrome , endocrinology , physiology , genetics , biology , genotype , gene , genetic variants
Observational studies have found shorter leukocyte telomere length (TL) to be a risk factor for coronary heart disease (CHD), and recently the association was suggested to be causal. However, the relationship between TL and common metabolic risk factors for CHD is not well understood. Whether these risk factors could explain pathways from TL to CHD warrants further attention.
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