Open AccessVEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling
Author(s) -
Krista Heinolainen,
Sinem Karaman,
Gabriela D’Amico,
Tuomas Tammela,
Raija Sormunen,
Lauri Eklund,
Kari Alitalo,
Georgia Zarkada
Publication year - 2017
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.116.310477
Subject(s) - vascular permeability , angiogenesis , vascular endothelial growth factor , kinase insert domain receptor , vascular endothelial growth factor c , vascular endothelial growth factor b , endothelial stem cell , vascular endothelial growth factor a , microbiology and biotechnology , blood vessel , biology , cancer research , endocrinology , vegf receptors , in vitro , biochemistry
Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas lymphangiogenesis signals are transduced by VEGFC/D via VEGFR3. VEGFR3 also regulates sprouting angiogenesis and blood vessel growth, but to what extent VEGFR3 signaling controls blood vessel permeability remains unknown.
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