Open AccessHuman Alternative Macrophages Populate Calcified Areas of Atherosclerotic Lesions and Display Impaired RANKL-Induced Osteoclastic Bone Resorption Activity
Author(s) -
Giulia Chinetti,
Mehdi Daoudi,
Mickaël Rosa,
Manjula Vinod,
Loı̈c Louvet,
Corinne Copin,
Mélanie Fanchon,
Jonathan Vanhoutte,
Bruno Derudas,
Loïc Belloy,
Stéphan Haulon,
Christophe Zawadzki,
Sophie Susen,
Ziad A. Massy,
Jérôme Eeckhoute,
Bart Staels
Publication year - 2017
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.116.310262
Subject(s) - cathepsin k , rankl , osteoclast , microbiology and biotechnology , mannose receptor , proinflammatory cytokine , cathepsin , biology , bone resorption , macrophage colony stimulating factor , chemistry , macrophage , activator (genetics) , cancer research , receptor , endocrinology , immunology , inflammation , in vitro , biochemistry , enzyme
Vascular calcification is a process similar to bone formation leading to an inappropriate deposition of calcium phosphate minerals in advanced atherosclerotic plaques. Monocyte-derived macrophages, located in atherosclerotic lesions and presenting heterogeneous phenotypes, from classical proinflammatory M1 to alternative anti-inflammatory M2 macrophages, could potentially display osteoclast-like functions.
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