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The National Institutes of Health (NIH) 2016 Progenitor Cell Biology Consortium (PCBC) and Cardiovascular Tissue Engineering (CVTE) Symposium was held on March 28, 2016 at Birmingham, AL (Figure). Over one hundred scientists, engineers, and trainees attended the symposium hosted by new joint Department of Biomedical Engineering, University of Alabama at Birmingham (UAB). The symposium was part of the NIH National Blood, Heart, and Lung Institute’s PCBC and featured information on the field’s latest accomplishments. The goal of the Symposium was to discuss novel approaches and cell and tissue engineering–based products to repair damaged heart and vasculature. The symposium sessions were aimed at the common topic of advancing the understanding of disease mechanisms and translating the most advanced basic science to preclinical and clinical trials. Because of the word limitation, this report could only highlight some of the presentations from this 1-day PCBC CVTE 2016 Symposiums. Many pertinent presentation summaries are not included, yet they certainly merit.Figure. 2016 PCBC symposium speakers.The opening remarks were given by Dr Jianyi Zhang and Dean J. Iwan D. Alexander (School of Engineering, UAB). Following the introductory remarks, 21 speakers presented their research topics in 12-minute lectures. This short presentation format was well acknowledged by the audience.Dr John P. Cooke (The Houston Methodist Research Institute) provided evidence that innate immune activation is essential for nuclear reprogramming to pluripotency, as well as transdifferentiation to another somatic lineage. His group showed that the viral vector for the Yamanaka factors was more than a mere vehicle.1 Stimulation of innate immunity by the viral vector (via TLR3 [toll-like receptor 3] and RIG-1 activation) causes global changes in epigenetic modifiers (eg, suppression of HDAC [histone deacetylases] family members and upregulation of HAT [histone acetyltransferases] proteins) that increases the probability of an open chromatin configuration. Antagonism of innate immunity …

Meeting Report for NIH 2016 Progenitor Cell Biology Consortium Cardiovascular Tissue Engineering 2016