Open AccessRasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II
Author(s) -
David M. Barry,
Yeon Koo,
Pieter R. Norden,
Lyndsay A. Wylie,
Ke Xu,
Chonlarat Wichaidit,
D. Berfin Azizoglu,
Yi Zheng,
Melanie H. Cobb,
George E. Davis,
Ondine Cleaver
Publication year - 2016
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.116.309094
Subject(s) - microbiology and biotechnology , rhoa , cdc42 , gtpase , biology , rac gtp binding proteins , rac1 , myosin light chain kinase , rock1 , morphogenesis , small gtpase , signal transduction , myosin , biochemistry , gene
Vascular tubulogenesis is essential to cardiovascular development. Within initial vascular cords of endothelial cells, apical membranes are established and become cleared of cell-cell junctions, thereby allowing continuous central lumens to open. Rasip1 (Ras-interacting protein 1) is required for apical junction clearance, as well as for regulation of Rho GTPase (enzyme that hydrolyzes GTP) activity. However, it remains unknown how activities of different Rho GTPases are coordinated by Rasip1 to direct tubulogenesis.
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