Open AccessCirculating Progenitor Cells Identify Peripheral Arterial Disease in Patients With Coronary Artery Disease
Author(s) -
Salim S. Hayek,
James P. MacNamara,
Ayman Samman Tahhan,
Mosaab Awad,
Adithya Yadalam,
YiAn Ko,
Seán Healy,
Iraj Hesaroieh,
Hina Ahmed,
Brandon Gray,
Salman Sher,
Nima Ghasemzadeh,
Riyaz S. Patel,
Jinhee Kim,
Edmund K. Waller,
Arshed A. Quyyumi
Publication year - 2016
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.116.308802
Subject(s) - arterial disease , coronary artery disease , medicine , peripheral , progenitor cell , cardiology , disease , vascular disease , artery , stem cell , biology , genetics
Peripheral arterial disease (PAD) is a clinical manifestation of extracoronary atherosclerosis. Despite sharing the same risk factors, only 20% to 30% of patients with coronary artery disease (CAD) develop PAD. Decline in the number of bone marrow-derived circulating progenitor cells (PCs) is thought to contribute to the pathogenesis of atherosclerosis. Whether specific changes in PCs differentiate patients with both PAD and CAD from those with CAD alone is unknown.
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