Open AccessGenome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3′-End Formation in the Failing Human Heart
Author(s) -
Esther E. Creemers,
Amira Bawazeer,
Alejandro P. Ugalde,
Hanneke W. M. van Deutekom,
Ingeborg van der Made,
Nina E. de Groot,
Michiel Adriaens,
Stuart A. Cook,
Connie R. Bezzina,
Norbert Hübner,
Jolanda van der Velden,
Ran Elkon,
Reuven Agami,
Yigal M. Pinto
Publication year - 2015
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.115.307082
Subject(s) - polyadenylation , three prime untranslated region , untranslated region , biology , gene , genetics , gene expression , messenger rna , microbiology and biotechnology
Alternative cleavage and polyadenylation (APA) of mRNA represents a layer of gene regulation that to date has remained unexplored in the heart. This phenomenon may be relevant, as the positioning of the poly(A) tail in mRNAs influences the length of the 3'-untranslated region (UTR), a critical determinant of gene expression.
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