Open AccessCardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function
Author(s) -
Konstantinos Drosatos,
Nina M. Pollak,
Christine J. Pol,
Panagiotis Ntziachristos,
Florian Willecke,
Mesele-Christina Valenti,
Chad M. Trent,
Yunying Hu,
Shaodong Guo,
Iannis Aifantis,
Ira J. Goldberg
Publication year - 2015
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.115.306383
Subject(s) - cardiac myocyte , myocyte , cardiac function curve , function (biology) , microbiology and biotechnology , medicine , biology , chemistry , endocrinology , heart failure
Fatty acid oxidation is transcriptionally regulated by peroxisome proliferator-activated receptor (PPAR)α and under normal conditions accounts for 70% of cardiac ATP content. Reduced Ppara expression during sepsis and heart failure leads to reduced fatty acid oxidation and myocardial energy deficiency. Many of the transcriptional regulators of Ppara are unknown.
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