Open AccessEsm1 Modulates Endothelial Tip Cell Behavior and Vascular Permeability by Enhancing VEGF Bioavailability
Author(s) -
Susana Rocha,
Maria Schiller,
Jing Ding,
Hang Li,
Stefan Butz,
Dietmar Vestweber,
Daniel Biljes,
Hannes C. A. Drexler,
Meliieminen-Kelhä,
Peter Vajkoczy,
Susanne Adams,
Rui Benedito,
Ralf H. Adams
Publication year - 2014
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.115.304718
Subject(s) - angiogenesis , vascular permeability , vascular endothelial growth factor , vascular endothelial growth factor a , inflammation , endothelial stem cell , endocrinology , medicine , microbiology and biotechnology , biology , biochemistry , in vitro , vegf receptors
Endothelial cell-specific molecule 1 (Esm1) is a secreted protein thought to play a role in angiogenesis and inflammation. However, there is currently no direct in vivo evidence supporting a function of Esm1 in either of these processes.
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