Open AccessPhosphorylation of Nox1 Regulates Association With NoxA1 Activation Domain
Author(s) -
Jennifer Streeter,
Brandon Schickling,
Shuxia Jiang,
Bojana Stanić,
William H. Thiel,
Lokesh Gakhar,
Jon C. D. Houtman,
Francis J. Miller
Publication year - 2014
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.115.304267
Subject(s) - nox1 , phosphorylation , nadph oxidase , microbiology and biotechnology , protein kinase a , kinase , biochemistry , biology , chemistry , reactive oxygen species
Activation of Nox1 initiates redox-dependent signaling events crucial in the pathogenesis of vascular disease. Selective targeting of Nox1 is an attractive potential therapy, but requires a better understanding of the molecular modifications controlling its activation.
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