Open AccessHuman Induced Pluripotent Stem Cell–Derived Cardiomyocytes as an In Vitro Model for Coxsackievirus B3–Induced Myocarditis and Antiviral Drug Screening Platform
Author(s) -
Arun Sharma,
Caleb Marceau,
Ryoko Hamaguchi,
Paul W. Burridge,
Kuppusamy Rajarajan,
Jared M. Churko,
Haodi Wu,
Karim Sallam,
Elena Matsa,
Anthony C. Sturzu,
Yonglu Che,
Antje Ebert,
Sebastian Diecke,
Ping Liang,
Kristy Red-Horse,
Jan E. Carette,
Sean M. Wu,
Joseph C. Wu
Publication year - 2014
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.115.303810
Subject(s) - coxsackievirus , myocarditis , virology , antiviral drug , viral myocarditis , biology , induced pluripotent stem cell , interferon , enterovirus , in vitro , enterovirus 71 , virus , medicine , gene , cardiology , embryonic stem cell , biochemistry
Viral myocarditis is a life-threatening illness that may lead to heart failure or cardiac arrhythmias. A major causative agent for viral myocarditis is the B3 strain of coxsackievirus, a positive-sense RNA enterovirus. However, human cardiac tissues are difficult to procure in sufficient enough quantities for studying the mechanisms of cardiac-specific viral infection.
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