Open AccessLRRC26 Is a Functional BK Channel Auxiliary γ Subunit in Arterial Smooth Muscle Cells
Author(s) -
Kirk W. Evanson,
John P. Bannister,
M. Dennis Leo,
Jonathan H. Jaggar
Publication year - 2014
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.115.303407
Subject(s) - bk channel , protein subunit , smooth muscle , myocyte , chemistry , medicine , microbiology and biotechnology , cardiology , anatomy , potassium channel , biology , biochemistry , gene
Smooth muscle cell (myocyte) large-conductance calcium (Ca)(2+)-activated potassium (BK) channels are functionally significant modulators of arterial contractility. Arterial myocytes express both pore-forming BKα and auxiliary β1 subunits, which increase channel Ca(2+) sensitivity. Recently, several leucine-rich repeat containing (LRRC) proteins have been identified as auxiliary γ subunits that elevate the voltage sensitivity of recombinant and prostate adenocarcinoma BK channels. LRRC expression and physiological functions in native cell types are unclear.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom