English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

> There is no part of the millet that does not make a sound […] .> > —Zenos’s paradox of the Grain of MilletJust 15 years ago, the amount of hematopoietic stem cells (HSC) circulating in peripheral blood (PB) was considered ≈0. In a healthy subject, out of ≈6000 leukocytes per microliter, HSCs expressing the typical marker CD34 account for ≈3 cells/μL (≈0.05% of total). In hematology, increased PB CD34+ cells indicate the timing for HSC collection after mobilization, and helps in the diagnosis of leukemia. However, there was no interest in understanding the clinical meaning of half-of-zero—a reduction in circulating CD34+ cells below normal values—until a role for bone marrow (BM)–derived cells in vascular homeostasis was hypothesized. The discovery of endothelial progenitor cells (EPC) has fostered a new era in cardiovascular research, focused on regeneration versus damage. Although still awaiting definite clinical demonstration, a wealth of experimental data indicates that EPCs promote vascular repair and angiogenesis.1Article, see p 289CD34 is a sialomucin adhesion molecule with unknown function, which identifies HSC in the BM. Small amounts of CD34+ HSC also circulate in PB and through peripheral organs. Although sources other than BM have been hypothesized, >90% of circulating CD34+ cells originate from the BM.2 Experimental and proof-of-concept human studies suggest that BM-derived HSC can repopulate the vasculature and parenchymatous organs beyond hematopoietic tissues.3 In fact, the function and biological meaning of steady-state PB CD34+ HSC is largely unknown. Far from being the result of a passive shedding from the BM, HSCs (and EPCs) are continuously released from the BM to PB after a circadian rhythm regulated by the autonomous …

A Look at the Bone Marrow Predicts the Global Outcome