Open AccessNitrite Therapy Improves Left Ventricular Function During Heart Failure via Restoration of Nitric Oxide–Mediated Cytoprotective Signaling
Author(s) -
Shashi Bhushan,
Kazuhisa Kondo,
David J. Polhemus,
Hiroyuki Otsuka,
Chad K. Nicholson,
YaXiong Tao,
Hui Huang,
Vasiliki V. Georgiopoulou,
Toyoaki Murohara,
John W. Calvert,
Javed Butler,
David J. Lefer
Publication year - 2014
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.114.301475
Subject(s) - heart failure , nitric oxide , nitrite , medicine , ejection fraction , sodium nitrite , cardiology , cardiac function curve , anesthesia , pharmacology , chemistry , nitrate , organic chemistry
Nitric oxide (NO) bioavailability is reduced in the setting of heart failure. Nitrite (NO2) is a critically important NO intermediate that is metabolized to NO during pathological states. We have previously demonstrated that sodium nitrite ameliorates acute myocardial ischemia/reperfusion injury.
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