Open AccessFocal Energy Deprivation Underlies Arrhythmia Susceptibility in Mice With Calcium-Sensitized Myofilaments
Author(s) -
Sabine Huke,
Raghav Venkataraman,
Michela Faggioni,
Sirish C. Bennuri,
Hyun Seok Hwang,
Franz Baudenbacher,
Björn C. Knollmann
Publication year - 2013
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.113.301055
Subject(s) - myofilament , calcium , medicine , cardiac arrhythmia , endocrinology , cardiology , microbiology and biotechnology , neuroscience , chemistry , biology , myocyte , atrial fibrillation
The Ca(2+) sensitivity of the myofilaments is increased in hypertrophic cardiomyopathy and other heart diseases and may contribute to a higher risk for sudden cardiac death. Ca(2+) sensitization increases susceptibility to reentrant ventricular tachycardia in animal models, but the underlying mechanism is unknown.
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