Open AccessCombined Deficiency in Glutathione Peroxidase 4 and Vitamin E Causes Multiorgan Thrombus Formation and Early Death in Mice
Author(s) -
Markus Wortmann,
Manuela Schneider,
Joachim Pircher,
Juliane Hellfritsch,
Michaela Aichler,
Vegi M. Naidu,
P. Kölle,
Peter Kuhlencordt,
Axel Walch,
Ulrich Pohl,
Georg W. Bornkamm,
Marcus Conrad,
Heike Beck
Publication year - 2013
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.113.279984
Subject(s) - vitamin e , glutathione peroxidase , vitamin e deficiency , peroxidase , thrombus , medicine , glutathione , endocrinology , biochemistry , chemistry , antioxidant , enzyme
Growing evidence indicates that oxidative stress contributes markedly to endothelial dysfunction. The selenoenzyme glutathione peroxidase 4 (Gpx4) is an intracellular antioxidant enzyme important for the protection of membranes by its unique activity to reduce complex hydroperoxides in membrane bilayers and lipoprotein particles. Yet a role of Gpx4 in endothelial cell function has remained enigmatic.
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