Open AccessNeutrophil-Derived Cathelicidin Promotes Adhesion of Classical Monocytes
Author(s) -
Sarawuth Wantha,
Jean-Éric Alard,
Remco T. A. Megens,
Anne M. van der Does,
Yvonne Döring,
Maik Drechsler,
Christine T. N. Pham,
MingWei Wang,
Jimin Wang,
Richard L. Gallo,
Philipp von Hundelshausen,
Lennart Lindbom,
Tilman M. Hackeng,
Christian Weber,
Oliver Soehnlein
Publication year - 2013
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.112.300666
Subject(s) - cathelicidin , adhesion , chemistry , monocyte , microbiology and biotechnology , cell adhesion , inflammation , immunology , biophysics , innate immune system , biology , biochemistry , receptor , organic chemistry
The leukocyte response in acute inflammation is characterized by an initial recruitment of neutrophils preceding a second wave of monocytes. Neutrophil-derived granule proteins were suggested to hold an important role in this cellular switch. The exact mechanisms by which neutrophils mediate these processes are only partially understood.
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