Open AccessHypoxia-Inducible Factor-1α in Pulmonary Artery Smooth Muscle Cells Lowers Vascular Tone by Decreasing Myosin Light Chain Phosphorylation
Author(s) -
Yu-Mee Kim,
Elizabeth A. Barnes,
Cristina M. Alvira,
Lihua Ying,
Sushma Reddy,
David N. Cornfield
Publication year - 2013
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.112.300646
Subject(s) - myosin light chain kinase , phosphorylation , hypoxia (environmental) , myosin , vascular smooth muscle , myosin light chain phosphatase , myh7 , vascular tone , medicine , pulmonary artery , cardiology , chemistry , smooth muscle , microbiology and biotechnology , endocrinology , biology , vasodilation , oxygen , organic chemistry
Hypoxia-inducible factor-1α (HIF-1α), an oxygen (O2)-sensitive transcription factor, mediates transcriptional responses to low-O2 tension states. Although acute hypoxia causes pulmonary vasoconstriction and chronic hypoxia can cause vascular remodeling and pulmonary hypertension, conflicting data exist on the role of HIF-1α in modulating pulmonary vascular tone.
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