Open AccessMicroRNA-10A* and MicroRNA-21 Modulate Endothelial Progenitor Cell Senescence Via Suppressing High-Mobility Group A2
Author(s) -
Shoukang Zhu,
Shanming Deng,
Qi Ma,
Taifang Zhang,
Chunling Jia,
Degen Zhuo,
Falin Yang,
Jianqin Wei,
Liyong Wang,
Derek M. Dykxhoorn,
Joshua M. Hare,
Pascal J. GoldschmidtClermont,
Chunming Dong
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.112.280016
Subject(s) - senescence , microrna , biology , progenitor cell , endothelial progenitor cell , microbiology and biotechnology , angiogenesis , stem cell , cancer research , downregulation and upregulation , genetics , gene
Endothelial progenitor cells (EPCs) contribute to the regeneration of endothelium. Aging-associated senescence results in reduced number and function of EPCs, potentially contributing to increased cardiac risk, reduced angiogenic capacity, and impaired cardiac repair effectiveness. The mechanisms underlying EPC senescence are unknown. Increasing evidence supports the role of microRNAs in regulating cellular senescence.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom