Open AccessMyofilament Ca Sensitization Increases Cytosolic Ca Binding Affinity, Alters Intracellular Ca Homeostasis, and Causes Pause-Dependent Ca-Triggered Arrhythmia
Author(s) -
Tilmann Schober,
Sabine Huke,
Raghav Venkataraman,
Oleksiy Gryshchenko,
Dmytro O. Kryshtal,
Hyun Seok Hwang,
Franz Baudenbacher,
Björn C. Knollmann
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.112.270041
Subject(s) - myofilament , sensitization , cytosol , troponin c , chemistry , homeostasis , medicine , afterdepolarization , endocrinology , troponin i , myocyte , biology , repolarization , biochemistry , electrophysiology , myocardial infarction , immunology , enzyme
Ca binding to the troponin complex represents a major portion of cytosolic Ca buffering. Troponin mutations that increase myofilament Ca sensitivity are associated with familial hypertrophic cardiomyopathy and confer a high risk for sudden death. In mice, Ca sensitization causes ventricular arrhythmias, but the underlying mechanisms remain unclear.
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