Open AccessImpaired Skeletal Muscle Blood Flow Control With Advancing Age in Humans
Author(s) -
Brett S. Kirby,
Anne R. Crecelius,
Wyatt F. Voyles,
Frank A. Dinenno
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.112.269571
Subject(s) - vasodilation , hypoxia (environmental) , skeletal muscle , medicine , endocrinology , deoxygenation , venous blood , blood flow , ageing , chemistry , biochemistry , oxygen , organic chemistry , catalysis
Skeletal muscle blood flow is coupled with the oxygenation state of hemoglobin in young adults, whereby the erythrocyte functions as an oxygen sensor and releases ATP during deoxygenation to evoke vasodilation. Whether this function is impaired in humans of advanced age is unknown.
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