Open AccessCes3/TGH Deficiency Improves Dyslipidemia and Reduces Atherosclerosis in Ldlr −/− Mice
Author(s) -
Jihong Lian,
Ariel D. Quiroga,
Lena Li,
Richard Lehner
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.112.267468
Subject(s) - ldl receptor , medicine , endocrinology , dyslipidemia , apolipoprotein b , lipoprotein , cholesterol , steatosis , very low density lipoprotein , receptor , biology , chemistry , diabetes mellitus
Carboxylesterase 3/triacylglycerol hydrolase (TGH) has been shown to participate in hepatic very low-density lipoprotein (VLDL) assembly. Deficiency of TGH in mice lowers plasma lipids and atherogenic lipoproteins without inducing hepatic steatosis.
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