Open AccessEnhanced Ca 2+ -Sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension
Author(s) -
Aya Yamamura,
Qiang Guo,
Hisao Yamamura,
Adriana M. Zimnicka,
Nicole M. Pohl,
Kimberly A. Smith,
Ruby A. Fernandez,
Amy Zeifman,
Ayako Makino,
Hui Dong,
Jason X.J. Yuan
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.112.266361
Subject(s) - extracellular , pulmonary hypertension , calcium sensing receptor , medicine , endocrinology , hypoxic pulmonary vasoconstriction , chemistry , calcium , calcium metabolism , biochemistry
A rise in cytosolic Ca(2+) concentration ([Ca(2+)](cyt)) in pulmonary arterial smooth muscle cells (PASMC) is an important stimulus for pulmonary vasoconstriction and vascular remodeling. Increased resting [Ca(2+)](cyt) and enhanced Ca(2+) influx have been implicated in PASMC from patients with idiopathic pulmonary arterial hypertension (IPAH).
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