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To the Editor:We have read with interest the article by Heusch et al1 showing that troponin I levels of 12 coronary artery bypass patients treated with remote ischemic preconditioning (rIPC) performed under isoflurane anesthesia were reduced when compared with those of 12 untreated control patients. In that study, phosphorylation of the transcription factor STAT5 was also increased after reperfusion in left ventricular tissue samples of patients treated with rIPC. These findings are promising and the researchers should be commended for their analysis of human ventricular tissue samples. However, from the article, it is unclear whether data from these patients were also published in a report recently published by the same group,2 which was conducted under the same ClinicalTrials identifier number. A comparison of the perioperative …

circulation research

Remote Ischemic Preconditioning Is Redundant in Patients Undergoing Coronary Artery Bypass Graft Surgery Who Are Already Protected by Volatile Anesthetics