Open AccessRegulator of G-Protein Signaling 5 Controls Blood Pressure Homeostasis and Vessel Wall Remodeling
Author(s) -
Vasyl Holobotovskyy,
Mitali Manzur,
Marianne Tare,
Jennifer Burchell,
Erin M. Bolitho,
Helena M. Viola,
Livia C. Hool,
Leonard Arnolda,
Douglas J. McKitrick,
Ruth Ganß
Publication year - 2013
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.111.300142
Subject(s) - angiotensin ii , regulator of g protein signaling , signal transduction , biology , rhoa , microbiology and biotechnology , vascular smooth muscle , homeostasis , endocrinology , medicine , protein kinase a , rho associated protein kinase , kinase , g protein , blood pressure , gtpase activating protein , smooth muscle
Regulator of G-protein signaling 5 (RGS5) modulates G-protein-coupled receptor signaling and is prominently expressed in arterial smooth muscle cells. Our group first reported that RGS5 is important in vascular remodeling during tumor angiogenesis. We hypothesized that RGS5 may play an important role in vessel wall remodeling and blood pressure regulation.
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