Open AccessTuning Electrical Conduction Along Endothelial Tubes of Resistance Arteries Through Ca 2+ -Activated K + Channels
Author(s) -
Erik J. Behringer,
Steven S. Segal
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.111.262592
Subject(s) - apamin , charybdotoxin , hyperpolarization (physics) , biophysics , gap junction , chemistry , membrane potential , acetylcholine , intracellular , potassium channel , endocrinology , biology , biochemistry , stereochemistry , nuclear magnetic resonance spectroscopy
Electrical conduction through gap junction channels between endothelial cells of resistance vessels is integral to blood flow control. Small and intermediate-conductance Ca(2+)-activated K(+) channels (SK(Ca)/IK(Ca)) initiate electrical signals in endothelial cells, but it is unknown whether SK(Ca)/IK(Ca) activation alters signal transmission along the endothelium.
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