Open AccessA Novel Role for Type 1 Angiotensin Receptors on T Lymphocytes to Limit Target Organ Damage in Hypertension
Author(s) -
Jian-dong Zhang,
Mehul Patel,
Young-Soo Song,
Robert Griffiths,
James L. Burchette,
Phillip Ruiz,
Matthew A. Sparks,
Ming Yan,
David N. Howell,
José A. Gómez,
Robert F. Spurney,
Thomas M. Coffman,
Steven D. Crowley
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.111.261768
Subject(s) - receptor , angiotensin ii , renin–angiotensin system , endocrinology , medicine , biology , microbiology and biotechnology , blood pressure
Human clinical trials using type 1 angiotensin (AT(1)) receptor antagonists indicate that angiotensin II is a critical mediator of cardiovascular and renal disease. However, recent studies have suggested that individual tissue pools of AT(1) receptors may have divergent effects on target organ damage in hypertension.
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