Open AccessBone Marrow–Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis
Author(s) -
Anouk A.J. Hamers,
Mariska Vos,
Fadi Rassam,
Goran Marinković,
Kondababu Kurakula,
Patrick J. van Gorp,
Menno P.J. de Winther,
Marion J. Gijbels,
Vivian de Waard,
Carlie J.M. de Vries
Publication year - 2011
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.111.260760
Subject(s) - nerve growth factor ib , bone marrow , macrophage , biology , nuclear receptor , cancer research , microbiology and biotechnology , endocrinology , immunology , transcription factor , in vitro , biochemistry , gene
Nuclear receptor Nur77, also known as NR4A1, TR3, or NGFI-B, is expressed in human atherosclerotic lesions in macrophages, endothelial cells, T cells and smooth muscle cells. Macrophages play a critical role in atherosclerosis and the function of Nur77 in lesion macrophages has not yet been investigated.
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