Nitrite-Mediated S -Nitrosylation of Caspase-3 Prevents Hypoxia-Induced Endothelial Barrier Dysfunction

Hypoxia is a significant perturbation that exacerbates endothelial barrier dysfunction, contributing to the disruption of vascular homeostasis and the development of various diseases such as atherosclerosis and metastasis of tumors. To date, it is not known what strategy might be used to counter the effect of hypoxia on endothelial permeability.