Open AccessLocation Matters
Author(s) -
Shikha Mishra,
Charles B.B. Gray,
Shigeki Miyamoto,
Donald M. Bers,
Joan Heller Brown
Publication year - 2011
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.111.248401
Subject(s) - phospholamban , cytosol , nuclear localization sequence , phosphorylation , subcellular localization , microbiology and biotechnology , endoplasmic reticulum , nuclear export signal , cell nucleus , chemistry , nucleus , biology , biochemistry , cytoplasm , enzyme
Differential effects of δ(B) and δ(C) subtypes of Ca²⁺/calmodulin-dependent protein kinase (CaMKII) on cardiomyocyte Ca²⁺ handling and survival have been suggested to result from their respective nuclear versus cytosolic localizations. CaMKIIδ subtype localization and its relationship to enzyme activation and target phosphorylation have not, however, been systematically evaluated.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom