Open AccessHCN3 Contributes to the Ventricular Action Potential Waveform in the Murine Heart
Author(s) -
Stefanie Fenske,
Robert M. Mader,
Andreas Scharr,
Christos Paparizos,
Xiaochun Cao-Ehlker,
Stylianos Michalakis,
Lior Shaltiel,
M. Weidinger,
Juliane Stieber,
Susanne Feil,
Robert Feil,
Franz Hofmann,
Christian WahlSchott,
Martin Biel
Publication year - 2011
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.111.246173
Subject(s) - repolarization , depolarization , ventricular action potential , hyperpolarization (physics) , medicine , membrane potential , cardiac action potential , myocyte , cardiology , sinoatrial node , electrophysiology , atrial action potential , chemistry , cardiac transient outward potassium current , endocrinology , patch clamp , heart rate , biochemistry , organic chemistry , nuclear magnetic resonance spectroscopy , blood pressure
The hyperpolarization-activated current I(h) that is generated by hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) plays a key role in the control of pacemaker activity in sinoatrial node cells of the heart. By contrast, it is unclear whether I(h) is also relevant for normal function of cardiac ventricles.
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