Open AccessRepression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction
Author(s) -
Shuang Zhou,
HouZao Chen,
Yan-zhen Wan,
Qingjun Zhang,
Yu-Sheng Wei,
Shuai Huang,
Jinjing Liu,
Yunbiao Lu,
ZhuQin Zhang,
Ruifeng Yang,
Ran Zhang,
Hua Cai,
DePei Liu,
ChihChuan Liang
Publication year - 2011
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.111.243592
Subject(s) - endothelial dysfunction , psychological repression , sirtuin 1 , endothelium , diabetes mellitus , microbiology and biotechnology , endocrinology , medicine , biology , gene expression , downregulation and upregulation , genetics , gene
Inactivation of the p66Shc adaptor protein confers resistance to oxidative stress and protects mice from aging-associated vascular diseases. However, there is limited information about the negative regulating mechanisms of p66Shc expression in the vascular system.
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