Open AccessOrai1 and CRAC Channel Dependence of VEGF-Activated Ca 2+ Entry and Endothelial Tube Formation
Author(s) -
Jing Li,
Richard M. Cubbon,
Lesley Wilson,
M. Samir Amer,
Lynn McKeown,
Bing Hou,
Yasser Majeed,
Sarka Tumova,
Victoria A. L. Seymour,
Hilary Taylor,
Martin Stacey,
David O’Regan,
Richard Foster,
Karen E. Porter,
Mark T. Kearney,
David J. Beech
Publication year - 2011
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.111.243352
Subject(s) - orai1 , microbiology and biotechnology , endothelial stem cell , calcium , t type calcium channel , voltage dependent calcium channel , calcium channel , stim1 , biology , vascular endothelial growth factor , chemistry , biochemistry , in vitro , cancer research , endoplasmic reticulum , organic chemistry , vegf receptors
Orai1 and the associated calcium release-activated calcium (CRAC) channel were discovered in the immune system. Existence also in endothelial cells has been suggested, but the relevance to endothelial biology is mostly unknown.
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