Open AccessPlacental Growth Factor Regulates Cardiac Adaptation and Hypertrophy Through a Paracrine Mechanism
Author(s) -
Federica Accornero,
Jop H. van Berlo,
Matthew J Benard,
John N. Lorenz,
Peter Carmeliet,
Jeffery D. Molkentin
Publication year - 2011
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.111.240820
Subject(s) - paracrine signalling , pressure overload , medicine , endocrinology , muscle hypertrophy , myocyte , heart failure , autocrine signalling , biology , basic fibroblast growth factor , growth factor , fibroblast growth factor , cardiac myocyte , microbiology and biotechnology , cardiac hypertrophy , receptor
Paracrine growth factor-mediated crosstalk between cardiac myocytes and nonmyocytes in the heart is critical for programming adaptive cardiac hypertrophy in which myocyte size, capillary density, and the extracellular matrix function coordinately.
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