Open AccessA Novel Hypoxia-Inducible Spliced Variant of Mitochondrial Death Gene Bnip3 Promotes Survival of Ventricular Myocytes
Author(s) -
Hongying Gang,
Hai Yan,
Rimpy Dhingra,
Joseph W. Gordon,
Natalia Yurkova,
Yaron Aviv,
Hongzhao Li,
Floribeth Aguilar,
Aaron J. Marshall,
Etienne Leygue,
Lorrie A. Kirshenbaum
Publication year - 2011
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.110.238709
Subject(s) - programmed cell death , microbiology and biotechnology , biology , myocyte , rna splicing , mitochondrion , alternative splicing , rna interference , apoptosis , messenger rna , gene , rna , genetics
Alternative splicing provides a versatile mechanism by which cells generate proteins with different or even antagonistic properties. Previously, we established hypoxia-inducible death factor Bnip3 as a critical component of the intrinsic death pathway.
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