Open AccessMARF and Opa1 Control Mitochondrial and Cardiac Function in Drosophila
Author(s) -
Gerald W. Dorn,
Charles F. Clark,
William H. Eschenbacher,
MinYoung Kang,
John T. Engelhard,
Stephen J. Warner,
Scot J. Matkovich,
Casey C. Jowdy
Publication year - 2010
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.110.236745
Subject(s) - mfn2 , mitochondrial fusion , mitochondrion , biology , microbiology and biotechnology , mitochondrial biogenesis , rna interference , dnaja3 , mitochondrial carrier , mitochondrial dna , gene knockdown , genetics , gene , bacterial outer membrane , rna , escherichia coli
Mitochondria interact via actions of outer and inner membrane fusion proteins. The role of mitochondrial fusion in functioning of the heart, where mitochondria comprise ≈30% of cardiomyocyte volume and their intermyofilament spatial arrangement with other mitochondria is highly ordered, is unknown.
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