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The urokinase plasminogen activator (uPA) system is among the most crucial pericellular proteolytic systems associated with the processes of angiogenesis. We previously identified an important regulator of the uPA system in the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R).

Soluble M6P/IGF2R Released by TACE Controls Angiogenesis via Blocking Plasminogen Activation