Open AccessBone Morphogenic Protein-4 Impairs Endothelial Function Through Oxidative Stress–Dependent Cyclooxygenase-2 Upregulation
Author(s) -
Wing Tak Wong,
Xiao Yu Tian,
Yangchao Chen,
Fung Ping Leung,
Limei Liu,
Hung Kay Lee,
ChiFai Ng,
Aimin Xu,
Xiaoqiang Yao,
Paul M. Vanhoutte,
George L. Tipoe,
Yü Huang
Publication year - 2010
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.110.222794
Subject(s) - downregulation and upregulation , oxidative stress , cyclooxygenase , microbiology and biotechnology , function (biology) , bone morphogenetic protein , oxidative phosphorylation , endothelial dysfunction , chemistry , medicine , endocrinology , biology , biochemistry , enzyme , gene
Bone morphogenic protein (BMP)4 can stimulate superoxide production and exert proinflammatory effects on the endothelium. The underlying mechanisms of how BMP4 mediates endothelial dysfunction and hypertension remain elusive.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom