Open AccessMicroRNAs As Circulating Biomarkers for Heart Failure: Questions About MiR-423-5p
Author(s) -
Regalla Kumarswamy,
Thomas Thum,
Stefan D. Anker
Publication year - 2010
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.110.220616
Subject(s) - heart failure , medicine , translational research , medical school , biomarker , population , pathology , medical education , biology , environmental health , biochemistry
To the Editor:With great interest, we read the recent article by Tijsen et al,1 who claimed to have identified several microRNAs (miRNAs) that may serve as attractive biomarker candidates for heart failure (HF), among which miR423-5p was most highly related to the clinical diagnosis of HF. We have concerns regarding the validity and completeness of presentation of statistical analyses, as well as regarding the study population that limit information gained from this publication.One of the major limitations of this study is sample size. Even the highest number of cases in any …
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