Open AccessTbx5 and Bmp Signaling Are Essential for Proepicardium Specification in Zebrafish
Author(s) -
Jiandong Liu,
Didier Y. R. Stainier
Publication year - 2010
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.110.217950
Subject(s) - bone morphogenetic protein , biology , zebrafish , microbiology and biotechnology , bmpr2 , transcription factor , bone morphogenetic protein 4 , signal transduction , bone morphogenetic protein 2 , genetics , gene , in vitro
The proepicardial organ (PE) contributes to the cellular diversity of the developing heart by giving rise to the epicardium as well as vascular smooth muscle cells and fibroblasts. Despite the importance of these cells in cardiac development, function and regeneration, the signals required for the specification of the PE remain largely unexplored.
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