Open AccessCircadian Clocks and Vascular Function
Author(s) -
Georgios K. Paschos,
Garret A. FitzGerald
Publication year - 2010
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.109.211706
Subject(s) - circadian rhythm , circadian clock , function (biology) , biology , vascular smooth muscle , neuroscience , vascular tone , medicine , endocrinology , microbiology and biotechnology , smooth muscle , vasodilation
The circadian clock regulates many aspects of physiology, including cardiovascular function. Internal oscillators exist in endothelial, smooth muscle cells, and fibroblasts of the vasculature. Vascular tone and thrombus formation, 2 key elements of vascular function with regard to adverse cardiovascular events, exhibit diurnal rhythmicity. In this review, we describe changes in vascular function that result from genetic disruption of discrete elements of the circadian clock.
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