Open AccessInvolvement of Phosphoinositide 3-Kinase γ in Angiogenesis and Healing of Experimental Myocardial Infarction in Mice
Author(s) -
Mauro Siragusa,
Rajesh Katare,
Marco Meloni,
Federico Damilano,
Emilio Hirsch,
Costanza Emanueli,
Paolo Madeddu
Publication year - 2010
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.109.207449
Subject(s) - pi3k/akt/mtor pathway , angiogenesis , neovascularization , phosphoinositide 3 kinase , protein kinase b , ly294002 , medicine , inflammation , downregulation and upregulation , kinase , cancer research , immunology , endocrinology , microbiology and biotechnology , signal transduction , biology , biochemistry , gene
Phosphoinositide 3-kinase (PI3K)gamma is expressed in hematopoietic cells, endothelial cells (ECs), and cardiomyocytes and regulates different cellular functions relevant to inflammation, tissue remodeling and cicatrization. Recently, PI3Kgamma inhibitors have been indicated for the treatment of chronic inflammatory/autoimmune diseases and atherosclerosis.
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