Open AccessAortic Arch Curvature and Atherosclerosis Have Overlapping Quantitative Trait Loci in a Cross Between 129S6/SvEvTac and C57BL/6J Apolipoprotein E–Null Mice
Author(s) -
Hirofumi Tomita,
Svetlana Zhilicheva,
Shinja Kim,
Nobuyo Maeda
Publication year - 2010
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.109.207175
Subject(s) - quantitative trait locus , aortic arch , apolipoprotein e , biology , lesion , locus (genetics) , medicine , chromosome , apolipoprotein b , genetics , pathology , aorta , endocrinology , cholesterol , gene , disease
Apolipoprotein E-null mice with a 129S6/SvEvTac strain background (129-apoE) develop atherosclerotic plaques faster in the aortic arch but slower in the aortic root than those with a C57BL/6J background (B6-apoE). The shape of the aortic arch also differs in the 2 strains.
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