Open AccessTRPM7-Mediated Ca 2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation
Author(s) -
Jianyang Du,
Jia Xie,
Zheng Zhang,
Hiroto Tsujikawa,
Daniel Fusco,
David I. Silverman,
Bruce T. Liang,
Lixia Yue
Publication year - 2010
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.109.206771
Subject(s) - trpm7 , myofibroblast , cardiac fibrosis , fibrosis , fibroblast , downregulation and upregulation , microbiology and biotechnology , medicine , transient receptor potential channel , endocrinology , chemistry , biology , cell culture , receptor , biochemistry , gene , genetics
Cardiac fibrosis contributes to pathogenesis of atrial fibrillation (AF), which is the most commonly sustained arrhythmia and a major cause of morbidity and mortality. Although it has been suggested that Ca(2+) signals are involved in fibrosis promotion, the molecular basis of Ca(2+) signaling mechanisms and how Ca(2+) signals contribute to fibrogenesis remain unknown.
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