Open AccessHypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells
Author(s) -
Gregory B. Waypa,
Jeremy D. Marks,
Robert D. Guzy,
Paul T. Mungai,
Jacqueline M. Schriewer,
Danijela Đokić,
Paul T. Schumacker
Publication year - 2009
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.109.206334
Subject(s) - cytosol , microbiology and biotechnology , hypoxia (environmental) , mitochondrion , hypoxic pulmonary vasoconstriction , reactive oxygen species , intracellular , mitochondrial ros , redox , biology , chemistry , biochemistry , oxygen , endocrinology , enzyme , vasoconstriction , organic chemistry
Recent studies have implicated mitochondrial reactive oxygen species (ROS) in regulating hypoxic pulmonary vasoconstriction (HPV), but controversy exists regarding whether hypoxia increases or decreases ROS generation.
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